Comfort Inn & Suites Sikeston I-55 Exterior photoComfort Inn & Suites Sikeston I-55 Exterior photoComfort Inn & Suites Sikeston I-55 Exterior photo
Book on our site
up to 10% cheaper
than Booking.com
Check rooms and rates
From108US$ /night
Check-in
20Jun2026Select date
Check-out
21Jun2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

109 Matthews Lane, Sikeston, Missouri, United States, 63801
-
Close to the Sikeston Depot Museum & Gallery
Very good
7.9
8.1
/10
3.6
3.6
/5

4-star pet-friendly hotel with indoor heated pool and hot tub in Sikeston

Amenities

The hotel offers an indoor heated swimming pool and spa facilities open year-round. A complimentary American breakfast is served daily with waffles, sausage, eggs, biscuits and gravy, cereal, muffins, and yogurt. Free high-speed Wi-Fi is available throughout the property.

Rooms

Guest rooms include King Suites and Queen Rooms with two queen beds, all non-smoking. Accessible rooms with walk-in showers and extra space are available for wheelchair users. The hotel provides room types suitable for families and business travelers.

Location

The hotel is near Bootheel Golf Club, a public golf course in Sikeston. Historic Sikeston Depot, a former railroad station turned museum, is a short drive away. Veterans Park offers outdoor recreation and is within walking distance.

Business

A business center with copy and fax services is available for guests. Free high-speed Wi-Fi supports remote work needs. The quiet location away from the highway helps with restful stays for business travelers.

Pet-Friendly

The hotel allows pets with a small fee, making it suitable for travelers with animals. Pet-friendly rooms are offered at reasonable rates. Ample on-site parking includes space for larger vehicles.

Highlights

Amenities: Indoor heated pool and hot tub

Rooms: King Suites and Queen Rooms with accessible options

Location: Near Bootheel Golf Club and Historic Sikeston Depot

Business: Business center with copy and fax services

Pet-Friendly: Pets allowed with reasonable fee and ample parking

Breakfast: Complimentary American breakfast daily

Must-do experiences

  • Savor a slice of famous Scott's BBQ for a true local flavor.
  • Visit the Sikeston Depot Museum for a glimpse into local history.
  • Catch a live performance at the historic Prophecy Palace Theatre.
  • Explore Sikeston's Farmers Market on Saturdays for fresh produce.
  • Discover the quaint shops at the Old Town Mall for unique finds.
View all

Select your room type

Comfort Inn & Suites Sikeston I-55 offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
King Room Non-Smoking
2 persons
360 sq. feet 
1 King-size bed
King Suite Non-Smoking
2 persons
360 sq. feet 
1 King-size bed
Queen Room Two Queen Beds Non-Smoking
2 persons
360 sq. feet 
2 King Size Beds
King Room Accessible or Non-Smoking
2 persons
1 King-size bed
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

Comfort Inn & Suites Sikeston I-55 offers amenities for your comfortable stay and unforgettable experiences
Facilities: Very good
7.7/10Review score

General

  • Wi-Fi
  • Free parking
  • Safe deposit box
  • Pets allowed

Children

  • Cots

Spa & Leisure

  • Indoor swimming pool

Bathroom

  • Washing machine

Media

  • AM/FM alarm clock
Show more

Comfort Inn & Suites Sikeston I-55 Location

109 Matthews Lane, Sikeston, Missouri, United States, 63801
Map view
109 Matthews Lane, Sikeston, Missouri, United States, 63801
Restaurants
Jd's Steakhouse & Saloon
3400 ft
4 N Interstate Dr
Explore Sikeston
Explore Sikeston
Top Attractions
Activities
Dining
Entertainment
Malco Sikeston Cinema & Grill
10-minute drive
A popular cinema offering the latest movies with comfortable seating and a full dining menu for a complete entertainment experience.
Sikeston Depot Museum & Gallery
15-minute drive
A historical museum showcasing Sikeston's railroad heritage, featuring local artifacts and interesting exhibits for all ages.
Sikeston Jaycee Bootheel Rodeo
10-minute drive
An annual rodeo event featuring thrilling bull riding and rodeo competitions, perfect for an exciting summer outing.
Boot Heel Golf Club
10-minute drive
A scenic golf course offering a challenging layout for golf enthusiasts, complemented by a relaxed, welcoming atmosphere.
Sikeston Sports Complex
10-minute drive
A family-friendly sports venue with various fields and courts for soccer and baseball, perfect for exercising and fun.
Relaxation at Local Parks
10-minute drive
Several parks in Sikeston offer serene walking trails and picnic areas, ideal for a relaxing day outdoors with nature.
Jd's Steakhouse & Saloon
13-minute walk
A laid-back steakhouse known for its prime cuts and hearty sides, offering a cozy atmosphere great for family gatherings.
Cheers Bar & Grille
10-minute drive
An inviting eatery featuring American classics and a vibrant bar scene with great daily specials, perfect for casual dining.
Malco Sikeston Cinema
10-minute drive
A local cinema featuring the latest films and a cozy atmosphere for a great movie night out with friends or family.
Bootheel Bar
10-minute drive
A lively bar known for its friendly vibe, featuring live music and events. An excellent place for socializing and entertainment.
Getting around
City Centre
Sikeston8 min  ·  3.0 mi
Airports
Cape Girardeau Regional (CGI)65 min  ·  26.7 mi
Barkley Regional (PAH)135 min  ·  55.9 mi
Want to see Exclusive Early Booking Rate?
Get exlusive rates right now!
Check Rates
Property information and rules
Check-in
from 14:00-23:59
Check-out
until 11 am
Guest Parking
Private parking is possible on site for free.
Internet
Wireless internet is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are allowed on request.
Year renovated:
2007
Number of rooms:
64

Reviews and Ratings

Feedback about Comfort Inn & Suites Sikeston I-55 from previous guests about their experience.
Review score
Based on 159 verified reviews
8.0/10
Great
78%
Recommend
Cleanliness
8.1/10
Comfort
8.0/10
Facilities
7.7/10
Free Wi-Fi
5.5/10
Location
8.7/10
Staff
8.4/10
Value for money
7.7/10
Guest reviews
based on 195 reviews
7.9/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews

Next best alternative

Consider them for your next trip.
Check-in
20Jun2026Select date
Check-out
21Jun2026Select date
Rooms and Guests2 Guests, 1 Room