Comfort Inn & Suites Santee I-95 Room photoComfort Inn & Suites Santee I-95 Interior photoComfort Inn & Suites Santee I-95 Exterior photo
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From117US$ /night
Check-in
20Jun2026Select date
Check-out
21Jun2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

221 Britain Street, Santee, South Carolina, United States, 29142
-
Near Santee National Wildlife Refuge
Very good
7.9
7.9
/10
3.3
3.3
/5

4-star hotel near Lake Marion with complimentary breakfast and seasonal outdoor pool

Amenities

The hotel offers a rich breakfast selection served by on-site breakfast staff each morning. A seasonal outdoor pool is available for relaxation during warmer months. Guests also have access to a well-maintained fitness center with accessible amenities.

Rooms

Spacious room layouts include a fridge and microwave for convenience. All units come with a seating area and a TV with satellite channels. The hotel provides rooms suitable for families and pets, with options for pullout beds accommodating groups of five.

Location & Outdoor Recreation

The hotel is located off Interstate 95, providing easy access to Santee Cooper Lakes and Santee National Wildlife Refuge. Guests can walk to nearby restaurants from the property. Santee Convention Center is also close for event attendees.

Business & Fitness

A business center with copy and fax services is available for corporate needs. The fitness center is equipped with a treadmill and bike, though the bike has been noted as non-functional. Express check-in and check-out processes are in place to save time.

Family & Pet-Friendly Services

The hotel accepts service animals only, with a well-lit outdoor area for late-night breaks. A 24-hour front desk staff assists with room changes and requests. Children are greeted with lollipops or cookies at check-in, and complimentary coffee is offered in the lobby.

Highlights

Breakfast: Rich hot breakfast with eggs, sausage, biscuits, gravy, waffles, and grits

Location: Off I-95, minutes from Lake Marion and Santee Cooper Lakes

Parking: Free private parking on-site, well-lit and accessible

Business: Business center with fax and copy services

Must-do experiences

  • Visit the Old Santee Canal Park for scenic nature trails.
  • Try the famous barbecue at J. Peters Grill & Bar in town.
  • Explore the historic Santee Cooper Lake for water activities.
  • Check out the Santee Farmers Market on Saturday mornings.
  • Tour the Santee Historical Society Museum for local history.
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Select your room type

Comfort Inn & Suites Santee I-95 offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Queen Suite Non-Smoking
2 persons
305 sq. feet 
2 King Size Beds
Heating
King Room Non-Smoking
2 persons
305 sq. feet 
1 King-size bed
Heating
Queen Room Two Queen Beds Non-Smoking
2 persons
305 sq. feet 
2 King Size Beds
Heating
King Suite Accessible or Non-Smoking
2 persons
1 King-size bed
Heating
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Facilities

Comfort Inn & Suites Santee I-95 offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.1/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Free parking
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Lift
  • Vending machines
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Housekeeping

Business

  • Business centre
  • Fax/Photocopying

Spa & Leisure

  • Seasonal outdoor pool

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities
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Comfort Inn & Suites Santee I-95 Location

221 Britain Street, Santee, South Carolina, United States, 29142
Map view
221 Britain Street, Santee, South Carolina, United States, 29142
Nearby
Santee Cajun Guide Service
1700 ft
Santee Presbyterian Church
1900 ft
Restaurants
Cracker Barrel
1000 ft
250 Britain St
Santee Seafood Bistro And Fresh Market
1000 ft
648 Bass Dr
Ziggy's Bar & Grill
1700 ft
8929 Old Hy #6
Captains Quarters
3300 ft
9053 Old Number Six Hwy
Explore Santee
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Santee Cooper Country Club
13 minutes' walk
A peaceful golf retreat known for its beautiful course and scenic views. Ideal for golf enthusiasts seeking a round of golf.
Santee Cajun Guide Service
6 minutes' walk
Guided fishing trips offered on Lake Marion. Suitable for all skill levels, this service provides a great day on the water.
Santee State Park
25 minutes' walk
A natural oasis with hiking trails and picnic areas. It offers stunning views of Lake Marion and opportunities for wildlife observation.
Santee Outlets
19 minutes' walk
A shopping destination featuring various brand-name stores at discounted prices. Great for fashion enthusiasts and gift shoppers.
Fishing with Santee Cajun Guide Service
6 minutes' walk
Experience guided fishing trips on Lake Marion. Perfect for thrill-seekers and nature lovers, all gear is provided.
Hiking at Santee State Park
25 minutes' walk
Explore scenic trails with varying difficulties. Ideal for travelers seeking relaxation or an immersive nature experience.
Golfing at Santee Cooper Country Club
13 minutes' walk
Play a round at this picturesque golf course. Suitable for all skill levels and offering a relaxing day outdoors.
Cracker Barrel
4 minutes' walk
Casual dining with classic American comfort food. Notable for its hearty breakfasts and cozy, family-friendly atmosphere.
Santee Seafood Bistro And Fresh Market
4 minutes' walk
Fresh seafood dishes in a laid-back setting. Known for its daily specials and local catch, catering to seafood lovers.
Ziggy's Bar & Grill
6 minutes' walk
Casual bar atmosphere serving American eats. Popular for its burgers and wings, and great for a laid-back evening with friends.
Captains Quarters
12 minutes' walk
A local bar with a relaxed vibe featuring live music and karaoke nights. Family-friendly atmosphere with games for all ages.
The Oasis Bar & Grill
40 minutes' walk
A vibrant spot with live entertainment. Great for night outs with friends, known for its lively atmosphere and delicious cocktails.
Getting around
City Centre
Santee18 min  ·  5000 ft
Airports
Charleston International (CHS)146 min  ·  60.1 mi
Columbia Metropolitan (CAE)148 min  ·  61.1 mi
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Property information and rules
Check-in
from 15:00-23:59
Check-out
until 11 am
Guest Parking
Private parking is possible on site for free.
Internet
Wireless internet is available in for free.
Breakfast
All visitors are offered a buffet breakfast for a fee. 
Children & extra beds
There are no extra beds provided in a room. 
Pets
Pets are not allowed.
Number of rooms:
61
Former name
Santee Inn & Suites

Reviews and Ratings

Feedback about Comfort Inn & Suites Santee I-95 from previous guests about their experience.
Review score
Based on 285 verified reviews
7.6/10
Very good
71%
Recommend
Cleanliness
8.3/10
Comfort
8.2/10
Facilities
8.1/10
Free Wi-Fi
7.5/10
Location
8.8/10
Staff
8.7/10
Value for money
7.9/10
Guest reviews
based on 305 reviews
7.9/10
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