Book on our site
Up to 10% cheaper
than Booking.com
Check rooms and rates
From332US$ /night
Check-in
15Mar2026Select date
Check-out
16Mar2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
-
Near the Jacksonville Beaches
Great
8.8
/10

Amenities

Hilton Jacksonville At Mayo Clinic is located steps from Mayo Clinic and offers specialized services like medical assistance and transportation for patients. The hotel includes an outdoor heated pool and a fitness center equipped with modern machines. Guests can enjoy complimentary parking along with access to business services.

Rooms

The hotel consists of 256 well-appointed guest rooms, designed for convenience and relaxation. Each accommodation comes with a large work desk, an ergonomic chair, and a mini-refrigerator. Select rooms feature views of the St. Johns River, allowing guests to relax with a scenic backdrop.

Location

Situated just off J. Turner Butler Blvd, the hotel provides easy access to popular destinations in Jacksonville. A short drive brings guests to the St. Johns Town Center, featuring shopping, dining, and entertainment options. The hotel is also conveniently located near Jacksonville Beach for relaxing seaside escapes.

Dining

Dining options at the Hilton Jacksonville At Mayo Clinic include the on-site restaurant, which offers a variety of dishes for breakfast, lunch, and dinner. The hotel has a bar and lounge that serves drinks and light snacks, catering to guests seeking to unwind. Room service is also available for those preferring to dine in privacy.

Business

The hotel accommodates business travelers with over 12,000 square feet of flexible event space, suitable for meetings and conferences. The business center offers essential services, including printing and copying, to support corporate needs. Complimentary Wi-Fi is available throughout the hotel, aiding connectivity during stays.

Highlights

Location: Steps from Mayo Clinic

Rooms: 256 well-appointed guest rooms

Dining: On-site restaurant offering diverse cuisine

Business: Over 12,000 square feet of flexible event space

Must-do experiences

  • Stroll through the beautiful Cummer Museum gardens for serenity.
  • Savor a Cuban sandwich at the historic Columbia Restaurant nearby.
  • Visit the Riverside Arts Market on Saturdays for local crafts.
  • Explore the vibrant murals of the Springfield neighborhood.
  • Take a sunset cruise along the St. Johns River for stunning views.
View all

Select your room type

Hilton Jacksonville At Mayo Clinic offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Queen Room Two Queen Beds Water View Hearing Accessible
2 persons
345 sq. feet 
2 King Size Beds
Shower
Heating
Queen Room Two Queen Beds Water View
2 persons
345 sq. feet 
2 King Size Beds
Shower
Heating
Queen Room Two Queen Beds Hearing Access
2 persons
345 sq. feet 
2 King Size Beds
Shower
Coffee machine
Queen Room Two Queen Beds
2 persons
345 sq. feet 
2 King Size Beds
Shower
Coffee machine
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

Hilton Jacksonville At Mayo Clinic offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Lift
  • ATM/Cash machine
  • Fireplace
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Shops/Commercial services
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Bar/ Lounge area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Outdoor swimming pool
  • Beach umbrellas
  • Sun loungers
  • Sun terrace
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries
  • Sink

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Curtains
Show more

Hilton Jacksonville At Mayo Clinic Location

4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
Map view
4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
Explore Jacksonville
Local Insights
Top Attractions
Activities
Dining
Entertainment
Windsor Parke Golf Club
25 minutes' walk
Golf course featuring an 18-hole championship layout, perfect for both beginners and seasoned players.
Castaway Island Preserve
40 minutes' walk
Nature preserve offering tranquility with trails, birdwatching spots, and scenic views of the marshes.
Urban Golf
35 minutes' walk
Indoor golfing facility providing technology-driven experiences for players of all skill levels.
Shipwreck Island Water Park
10 minutes' drive
Family-friendly water park featuring slides, wave pools, and lazy rivers, ideal for adventure seekers.
Bonefish Grill
5 minutes' drive
Offering a seafood-centric menu in an upscale setting, renowned for its Bang Bang Shrimp and fresh catches.
Mellow Mushroom
5 minutes' drive
Casual eatery known for creative pies and a vibrant atmosphere, with vegetarian and gluten-free options.
Regal Cinema
10 minutes' drive
Modern cinema featuring the latest blockbusters, with comfortable seating and tasty concessions.
Area 51 Laser Tag
10 minutes' drive
Interactive laser tag arena offering fun for all ages, perfect for families looking for exciting outings.
Getting around
City Centre
Jacksonville33 min  ·  13.6 mi
Airports
Jacksonville International Airport (JAX)67 min  ·  27.5 mi
St. Augustine, FL (UST)71 min  ·  29.0 mi
Train
Jacksonville Electric Authority Southside Generating Station Wharf29 min  ·  11.8 mi
Union Station35 min  ·  14.4 mi
Want to see Exclusive Early Booking Rate?
Get exlusive rates right now!
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Internet
Wireless internet is available in for free.
Pets
Pets are not allowed.
Number of rooms:
252

Reviews and Ratings

Feedback about Hilton Jacksonville At Mayo Clinic from previous guests about their experience.
Review score
Based on 9 verified reviews
8.6/10
Great
82%
Recommend
Guest reviews
based on 57 reviews
8.8/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews

Next best alternative

Consider them for your next trip.
Check-in
15Mar2026Select date
Check-out
16Mar2026Select date
Rooms and Guests2 Guests, 1 Room